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- Title
A novel mutation of SETBP1 in atypical chronic myeloid leukemia transformed from acute myelomonocytic leukemia.
- Authors
Hu, WangQiang; Wang, XiaoXia; Yang, RongRong; Xie, YaoSheng; Zhang, Zhuo; Lu, Hong; Wu, LianFeng; Lai, MeiMei; Yu, Kang
- Abstract
Key Clinical Message To investigate an oncogenic mutation of SETBP1 in the evolution from acute myelomonocytic leukemia (M4) to secondary aCML. Clinical data and molecular studies were analyzed of paired aCML and 'normal' DNA from a case with M4. We identified a mutation in SETBP1 (encoding a p.Asp868Ala alteration). The analysis of paired sample indicated that SETBP1 mutation was acquired during leukemic evolution.
- Subjects
BLOOD cell count; BONE marrow cancer; CANCER chemotherapy; ALKALINE phosphatase
- Publication
Clinical Case Reports, 2015, Vol 3, Issue 6, p448
- ISSN
2050-0904
- Publication type
Article
- DOI
10.1002/ccr3.243