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- Title
Interference in thyroid function immunoassays: clinical consequences.
- Authors
Kuzmanovska, Sonja; Vaskova, Olivija
- Abstract
Thyroid function tests are prone to analytical interference, which can cause misleading results when performed on automated immunoassay analyzers. We present a case of a 68-years old woman diagnosed with primary hypothyroidism and chronically treated with levothyroxine. Her status has been followed-up in several different institutions and before readmission to our institute, she was diagnosed as T3 toxicosis according to the lab results of suppressed TSH, normal FT4 and highly elevated FT3 values. Due to lack of toxic symptoms, our clinician suspected FT3 test interference, which was confirmed in our lab by performing the test on a different immunoassay platform. In conclusion, every discrepancy between clinical presentation and laboratory test results has to be inspected by close communication between clinicians and laboratory specialists. Our goal was to raise the awareness within the healthcare community about the interference in immunoassays affecting different kit manufacturers and analytical platforms in order to avoid erroneous diagnosis and mistreatment of patients.
- Subjects
IMMUNOASSAY; THYROID gland function tests; MEDICAL personnel; THYROID gland; DIAGNOSIS
- Publication
Macedonian Pharmaceutical Bulletin / Makedonsko Farmacevtski Bilten, 2020, Vol 66, Issue 1, p3
- ISSN
1409-8695
- Publication type
Article
- DOI
10.33320/maced.pharm.bull.2020.66.01.008