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- Title
Insulin-like growth factor-1 alters apoptotic signalling in prostate cancer.
- Authors
Watson, R W G; O'Brien, F; Coffey, R N T; Fitzpatrick, J M
- Abstract
Serum insulin-like growth factor-1 (IGF-1) levels have been correlated with an increased risk of developing prostate cancer. The progression from androgen-dependent to androgen-independent prostate cancer is thought to be due to survival factors inducing apoptotic resistance in these cells. IGF-1 may represent a novel survival factor in prostate cancer. Over-expression of focal adhesion kinase (FAK) and anti-apoptotic proteins correlates with an increased metastatic phenotype. The aim of this study was to determine if IGF-1 alters prostate cancer cell resistance to chemical and radiation induced apoptosis, and to examine the intracellular signalling mechanisms involved.
- Subjects
INSULIN; GROWTH factors; APOPTOSIS; PROSTATE cancer
- Publication
Prostate Cancer & Prostatic Diseases, 2000, Vol 3, Issue 4, pS42
- ISSN
1365-7852
- Publication type
Article
- DOI
10.1038/sj.pcan.4500468