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- Title
Hepatoid variant of yolk sac tumor of the testis.
- Authors
Horie, Yasushi; Kato, Masako
- Abstract
A case of testicular yolk sac tumor (endodermal sinus tumor) consisting predominantly of hepatoid cells is documented. A mass measuring approximately 4 × 3 cm was noted in the left testis of a 64-year-old man. Preoperative examination revealed an elevated serum level of α-fetoprotein (5479 ng/mL). Histologically, the lesion was composed predominantly of sheet-like or trabecular proliferation of hepatocyte-like cells with eosinophilic or clear cytoplasm. The tumor cells were immunoreactive for α-fetoprotein, antimitochondrial antibody, cytokeratin (AE1/AE3), α-1-antichymotrypsin, α-1-antitrypsin, albumin, carcinoembryonic antigen and epithelial membrane antigen. It was necessary to distinguish this variant lesion from metastatic hepatocellular carcinoma, embryonal carcinoma and hepatoid carcinoma.
- Subjects
TESTIS tumors; ENDODERMAL sinus tumors
- Publication
Pathology International, 2000, Vol 50, Issue 9, p754
- ISSN
1320-5463
- Publication type
Article
- DOI
10.1046/j.1440-1827.2000.01102.x