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- Title
Mayaro Virus Induction of Oxidative Stress is Associated With Liver Pathology in a Non-Lethal Mouse Model.
- Authors
da Silva Caetano, Camila Carla; Camini, Fernanda Caetano; Almeida, Letícia Trindade; Ferraz, Ariane Coelho; da Silva, Tales Fernando; Lima, Rafaela Lameira Souza; de Freitas Carvalho, Mayara Medeiros; de Freitas Castro, Thalles; Carneiro, Cláudia Martins; de Mello Silva, Breno; de Queiroz Silva, Silvana; de Magalhães, José Carlos; de Brito Magalhães, Cintia Lopes
- Abstract
Mayaro virus (MAYV) causes Mayaro fever in humans, a self-limiting acute disease, with persistent arthralgia and arthritis. Although MAYV has a remerging potential, its pathogenic mechanisms remain unclear. Here, we characterized a model of MAYV infection in 3–4-week BALB/c mice. We investigated whether the liver acts as a site of viral replication and if the infection could cause histopathological alterations and an imbalance in redox homeostasis, culminating with oxidative stress. MAYV-infected mice revealed lower weight gain; however, the disease was self-resolving. High virus titre, neutralizing antibodies, and increased levels of aspartate and alanine aminotransferases were detected in the serum. Infectious viral particles were recovered in the liver of infected animals and the histological examination of liver tissues revealed significant increase in the inflammatory infiltrate. MAYV induced significant oxidative stress in the liver of infected animals, as well as a deregulation of enzymatic antioxidant components. Collectively, this is the first study to report that oxidative stress occurs in MAYV infection in vivo, and that it may be crucial in virus pathogenesis. Future studies are warranted to address the alternative therapeutic strategies for Mayaro fever, such as those based on antioxidant compounds.
- Subjects
ACUTE diseases; VIRUS diseases; OXIDATIVE stress; JOINT pain; AMINOTRANSFERASES; ANTIOXIDANTS
- Publication
Scientific Reports, 2019, Vol 9, Issue 1, pN.PAG
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-019-51713-9