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- Title
Correlation between Histopathological Prognostic Tumor Characteristics and [ 18 F]FDG Uptake in Corresponding Metastases in Newly Diagnosed Metastatic Breast Cancer.
- Authors
Boers, Jorianne; Eisses, Bertha; Zwager, Mieke C.; van Geel, Jasper J. L.; Bensch, Frederike; de Vries, Erik F. J.; Hospers, Geke A. P.; Glaudemans, Andor W. J. M.; Brouwers, Adrienne H.; den Dekker, Martijn A. M.; Elias, Sjoerd G.; Kuip, Evelien J. M.; van Herpen, Carla M. L.; Jager, Agnes; van der Veldt, Astrid A. M.; Oprea-Lager, Daniela E.; de Vries, Elisabeth G. E.; van der Vegt, Bert; Menke-van der Houven van Oordt, Willemien C.; Schröder, Carolina P.
- Abstract
Background: In metastatic breast cancer (MBC), [18F]fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) can be used for staging. We evaluated the correlation between BC histopathological characteristics and [18F]FDG uptake in corresponding metastases. Patients and Methods: Patients with non-rapidly progressive MBC of all subtypes prospectively underwent a baseline histological metastasis biopsy and [18F]FDG-PET. Biopsies were assessed for estrogen, progesterone, and human epidermal growth factor receptor 2 (ER, PR, HER2); Ki-67; and histological subtype. [18F]FDG uptake was expressed as maximum standardized uptake value (SUVmax) and results were expressed as geometric means. Results: Of 200 patients, 188 had evaluable metastasis biopsies, and 182 of these contained tumor. HER2 positivity and Ki-67 ≥ 20% were correlated with higher [18F]FDG uptake (estimated geometric mean SUVmax 10.0 and 8.8, respectively; p = 0.0064 and p = 0.014). [18F]FDG uptake was lowest in ER-positive/HER2-negative BC and highest in HER2-positive BC (geometric mean SUVmax 6.8 and 10.0, respectively; p = 0.0058). Although [18F]FDG uptake was lower in invasive lobular carcinoma (n = 31) than invasive carcinoma NST (n = 146) (estimated geometric mean SUVmax 5.8 versus 7.8; p = 0.014), the metastasis detection rate was similar. Conclusions: [18F]FDG-PET is a powerful tool to detect metastases, including invasive lobular carcinoma. Although BC histopathological characteristics are related to [18F]FDG uptake, [18F]FDG-PET and biopsy remain complementary in MBC staging (NCT01957332).
- Subjects
METASTATIC breast cancer; LOBULAR carcinoma; EPIDERMAL growth factor receptors; METASTASIS; HISTOPATHOLOGY; POSITRON emission tomography
- Publication
Diagnostics (2075-4418), 2024, Vol 14, Issue 4, p416
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics14040416