We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Phosphatidylinositol 4-Phosphate 5-Kinases in the Regulation of T Cell Activation.
- Authors
Porciello, Nicla; Kunkl, Martina; Viola, Antonella; Tuosto, Loretta; Sho Yamasaki; Nunes, Jacques A.
- Abstract
Phosphatidylinositol 4,5-biphosphate kinases (PIP5Ks) are critical regulators of T cell activation being the main enzymes involved in the synthesis of phosphatidylinositol 4,5-biphosphate (PIP2). PIP2 is indeed a pivotal regulator of the actin cytoskeleton, thus controlling T cell polarization and migration, stable adhesion to antigen-presenting cells, spatial organization of the immunological synapse, and co-stimulation. Moreover, PIP2 also serves as a precursor for the second messengers inositol triphosphate, diacylglycerol, and phosphatidylinositol 3,4,5-triphosphate, which are essential for the activation of signaling pathways regulating cytokine production, cell cycle progression, survival, metabolism, and differentiation. Here, we discuss the impact of PIP5Ks on several T lymphocyte functions with a specific focus on the role of CD28 co-stimulation in PIP5K compartimentalization and activation.
- Subjects
T cells; PHOSPHOINOSITIDES; PHOSPHATIDYLINOSITOL 3-kinases; PHYSIOLOGY
- Publication
Frontiers in Immunology, 2016, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2016.00186