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- Title
Standard treatment forHelicobacter pyloriinfection is suboptimal in non-ulcer dyspepsia compared with duodenal ulcer in Chinese.
- Authors
Wong, W. M.; Xiao, S. D.; Hu, P. J.; Wang, W. H.; Gu, Q.; Huang, J. Q.; Xia, H. H.‐X.; Wu, S. M.; Li, C. J.; Chen, M. H.; Cui, Y.; Lai, K. C.; Hu, W. H. C.; Chan, C. K.; Lam, S. K.; Wong, B. C.‐Y.
- Abstract
: Recent studies suggest that theHelicobacter pylorieradication rate in patients with non-ulcer dyspepsia is lower when compared to patients with peptic ulcer diseases.: The aim of this study was to study the efficacy of triple therapy forH. pyloriinfection in patients with duodenal ulcer vs. patients with non-ulcer dyspepsia.: A total of 582 Chinese patients with provenH. pyloriinfection were recruited to receive: omeprazole 20 mg, amoxicillin 1000 mg and clarithromycin 500 mg all given twice daily for 7 days (OCA regime). Endoscopy with rapid urease test, histology and culture were performed before treatment. Post-treatmentH. pyloristatus was determined by13C-urea breath test. Metronidazole, clarithromycin and amoxicillin resistance was defined as minimum inhibitory concentration (MIC) of>8 μg/mL,>1 μg/mL and>1 μg/mL, respectively.: A significantly higher (intention-to-treat/per-protocol) eradication rate was found in patients with duodenal ulcer than those with non-ulcer dyspepsia (91/94% vs. 84/88% respectively,P = 0.011 andP = 0.016). Clarithromycin resistance rate was higher in patients with non-ulcer dyspepsia than those with duodenal ulcer (14% vs. 6%,P = 0.015). Clarithromycin resistance (40% vs. 5%,P < 0.001, OR 12, 95% CI: 5.7–24.3) and the diagnosis of non-ulcer dyspepsia (91% vs. 84%,P = 0.011, OR 2.0, 95% CI: 1.2–3.3) significantly affected the success ofH. pylorieradication.: Clarithromycin resistance accounts for the significantly lower and suboptimalH. pylorieradication rate of OCA regimen in Chinese patients with non-ulcer dyspepsia compared to those with duodenal ulcer.
- Subjects
HELICOBACTER pylori infections; INDIGESTION; PEPTIC ulcer; BREATH tests; ENDOSCOPY; HISTOPATHOLOGY; DIAGNOSIS
- Publication
Alimentary Pharmacology & Therapeutics, 2005, Vol 21, Issue 1, p73
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2004.02283.x