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- Title
Acid inhibition on the first day of dosing: comparison of four proton pump inhibitors.
- Authors
Pantoflickova, D.; Dorta, G.; Ravic, M.; Jornod, P.; Blum, A. L.
- Abstract
Summary Background: Rapid and consistent acid suppression on the first day of dosing may be important in treating acid-related disorders. Aim: To compare the antisecretory activity and onset of action of single doses of rabeprazole, lansoprazole, pantoprazole, omeprazole capsule, omeprazole multiple unit pellet system (MUPS) tablet and placebo in healthy Helicobacter pylori -negative subjects. Methods: This cross-over, double-blind, randomized study was performed in 18 H. pylori -negative subjects. Twenty-four-hour intragastric pH monitoring was performed on the day of treatment (once-daily dose of rabeprazole 20 mg, lansoprazole 30 mg, pantoprazole 40 mg, omeprazole capsule 20 mg, omeprazole MUPS tablet 20 mg or placebo). Results: The intragastric pH (3.4) and time at pH > 4 during the 24 h post-dose (8.0 h) were significantly greater with rabeprazole than with lansoprazole, pantoprazole, omeprazole capsule, omeprazole MUPS tablet or placebo (P ≤ 0.04 for rabeprazole vs. the others). Daytime and night-time pH values were higher with rabeprazole and lansoprazole than with pantoprazole, omeprazole capsule and omeprazole MUPS tablet (P ≤ 0.04). Conclusion: Rabeprazole was the most potent acid inhibitor of all the proton pump inhibitors tested during the first day of dosing.
- Subjects
PROTON pump inhibitors; ANTACIDS; OMEPRAZOLE; HELICOBACTER pylori
- Publication
Alimentary Pharmacology & Therapeutics, 2003, Vol 17, Issue 12, p1507
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1046/j.1365-2036.2003.01496.x