We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Control of intragastric acidity with over-the-counter doses of ranitidine or famotidine.
- Authors
Hamilton, M. I.; Sercombe, J.; Pounder, R. E.
- Abstract
Background:Histamine H2-receptor antagonists are available over the counter for the treatment of heartburn. Aim:To compare the effects of low doses of ranitidine and famotidine on intragastric acidity in a three-way crossover study. Methods:Healthy subjects (12 male, 12 female) were dosed on three occasions with single oral doses of placebo, ranitidine, 75 mg, and famotidine, 10 mg, 1 h after lunch. The pH of gastric aspirates was then measured for 20 h. Subjects ate standard meals and snacks. Analysis of variance was used to determine the statistical significance of differences in acidity (mmol/L) during the day (12.30–22.30 hours) and night (22.30–08.30 hours). Results:Ranitidine and famotidine were superior (P < 0.05) to placebo in decreasing acidity for daytime and night-time intervals. There were no significant differences in mean gastric acidity between ranitidine and famotidine during the daytime (11.37 mmol/L vs. 13.42 mmol/L, respectively) and night-time (23.57 mmol/L vs. 24.74 mmol/L, respectively). Intragastric acidity after ranitidine was significantly lower than that after famotidine in the first 2.5-h period following dosing (4.32 mmol/L vs. 9.28 mmol/L; P < 0.05). Conclusions:Lunchtime doses of ranitidine and famotidine decreased acidity during day- and night-time periods. The effect of ranitidine was significantly greater for the first 2.5 h after dosing.
- Subjects
GASTRIC acid; RANITIDINE; PLACEBOS; SECRETION
- Publication
Alimentary Pharmacology & Therapeutics, 2001, Vol 15, Issue 10, p1579
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1046/j.1365-2036.2001.01091.x