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- Title
The regulatory role of microRNAs in common eye diseases: A brief review.
- Authors
Benavides-Aguilar, Javier A.; Morales-Rodríguez, Jonathan I.; Ambriz-González, Héctor; Ruiz-Manriquez, Luis M.; Banerjee, Antara; Pathak, Surajit; Duttaroy, Asim K.; Paul, Sujay
- Abstract
MicroRNAs (miRNAs) are highly conserved, small non-coding RNA molecules (~21 nucleotides) that regulate numerous biological processes, including developmental timing, hematopoiesis, organogenesis, apoptosis, cell differentiation, and proliferation either by mRNA degradation or translation repression. Since eye physiology requires a perfect orchestration of complex regulatory networks, an altered expression of key regulatory molecules such as miRNAs potentially leads to numerous eye disorders. In recent years, comprehensive progress has been made in demonstrating the precise roles of miRNAs, emphasizing their potential use in diagnostic and therapeutic purposes of chronic human diseases. Thus, this review explicitly illustrates the regulatory roles of miRNAs in four common eye disorders, such as cataract, glaucoma, macular degeneration, and uveitis, and their application in disease management.
- Subjects
EYE diseases; MACULAR degeneration; MICRORNA; EYE physiology; CELL differentiation; NON-coding RNA; MESSENGER RNA
- Publication
Frontiers in Genetics, 2023, Vol 14, p1
- ISSN
1664-8021
- Publication type
Article
- DOI
10.3389/fgene.2023.1152110