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- Title
Regeneration, health status and quality of life after rhG-CSF-stimulated stem cell collection in healthy donors: a cross-sectional study.
- Authors
Leitner, G. C.; Baumgartner, K.; Kalhs, P.; Biener, D.; Greinix, H. T.; Hoecker, P.; Worel, N.
- Abstract
Mobilized allogeneic PBPC are increasingly used instead of BM for allogeneic stem cell grafting. Although the short-term safety profile of recombinant human (rh)G-CSF seems acceptable, only minimal data on long-term safety are available. We therefore reviewed data on 171 sibling donors (M/F: 98/73) with respect to side effects of rhG-CSF and PBPC collection and impact on quality of life (QoL) and health status. In a cross-sectional study, we investigated the actual QoL and health status of the donors as well as the need for medical treatment since PBPC donation by a questionnaire that was sent to 151 donors. Ninety-five (64%) of the addressed donors responded to the questionnaire, but only 69 (46%) of them reported on their actual health status and QoL, which was good to very good in the majority of them. Two donors developed malignancies in the post-donation course. In general, PBPC collection after rhG-CSF mobilization was well tolerated by the responding donors. Although the reported events in medical history after PBPC donation do not seem to be associated with rhG-CSF administration or the collection procedure, a lifelong follow-up of donors should be obligatory.Bone Marrow Transplantation (2009) 43, 357–363; doi:10.1038/bmt.2008.335; published online 20 October 2008
- Subjects
BLOOD donors; REGENERATION (Biology); HEALTH status indicators; HOMOGRAFTS; BONE marrow transplantation; HEALTH
- Publication
Bone Marrow Transplantation, 2009, Vol 43, Issue 5, p357
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/bmt.2008.335