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- Title
Common genetic variation in the type A endothelin-1 receptor is associated with ambulatory blood pressure: a family study.
- Authors
Rahman, T.; Baker, M.; Hall, D. H.; Avery, P. J.; Keavney, B.
- Abstract
The endothelins are among the most potent vasoconstrictors known. Pharmacological inhibition of endothelin receptors lowers blood pressure (BP). It is unknown whether naturally occurring genetic variation in the endothelin receptors influences BP. We have evaluated the type A endothelin receptor (EDNRA) as a candidate gene for hypertension in a large family study. A total of 1425 members of 248 families selected via a proband with hypertension were studied. Ambulatory BP monitoring was conducted using the A&D TM2421 device. Four haplotype-tagging single nucleotide polymorphisms (SNPs) spanning the EDNRA gene were typed. There was evidence of association between genotype at the rs5335 (C+70G) SNP and night systolic blood pressure (+1.24% (s.e. 0.64) per G allele; P=0.05); night diastolic blood pressure (+1.64% (s.e. 0.71) per G allele; P=0.021) and night mean BP (+1.51% (s.e. 0.64) per G allele; P=0.017). Borderline significant trends in the same direction were seen for daytime BPs. Proportions of hypertensives in each of the three genotype groups were C/C 34.7%, C/G 37.9%, G/G 42.4% yielding an odds ratio for hypertension per G allele of 1.19 (95% confidence interval 1.00–1.41; P=0.05). In conclusion, the rs5335 (C+70G) polymorphism of the EDNRA gene has small effects on the risk of hypertension. Natural variation in other genes in the endothelin-signalling pathway should be explored to identify additional influences on BP regulation.Journal of Human Hypertension (2008) 22, 282–288; doi:10.1038/sj.jhh.1002322; published online 3 January 2008
- Subjects
HUMAN genetic variation; ENDOTHELINS; AMBULATORY blood pressure monitoring; VASOCONSTRICTORS; BLOOD pressure; GENETIC research
- Publication
Journal of Human Hypertension, 2008, Vol 22, Issue 4, p282
- ISSN
0950-9240
- Publication type
Article
- DOI
10.1038/sj.jhh.1002322