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- Title
Lats2 is critical for the pluripotency and proper differentiation of stem cells.
- Authors
Aylon, Y; Sarver, A; Tovy, A; Ainbinder, E; Oren, M
- Abstract
Differentiation is a highly controlled process essential for embryonic and adult development. Moreover, disruption of proper differentiation is often associated with human diseases, including cancer. We analyzed the involvement of the tumor-suppressor Lats2 in mouse embryonic stem cell (mESC) pluripotency and differentiation, and report that mESCs lacking Lats2 are unable to sustain stemness and are not able to initiate and coordinate developmental transcriptional programs. Lats2−/− mESCs retain bivalent 'poised' chromatin marks on developmental genes and exhibit germ layer ambiguity both in vitro and in vivo. Importantly, in coordinating proper germ layer specification, Lats2 engages in a feedback loop with another tumor suppressor, p53.
- Subjects
PLURIPOTENT stem cells; CELL differentiation; TUMOR suppressor genes; EMBRYONIC stem cell research; CHROMATIN
- Publication
Cell Death & Differentiation, 2014, Vol 21, Issue 4, p624
- ISSN
1350-9047
- Publication type
Article
- DOI
10.1038/cdd.2013.188