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- Title
In This Issue.
- Abstract
This document is a summary of articles published in the journal International Immunology. The first article discusses the novel roles of IL-21 in regulating germinal centers, which are important for B cell differentiation and antibody responses. The authors highlight the key role of IL-21 in promoting GC expansion, shaping B-cell polarization, and regulating the positive selection of B cells. They also discuss how IL-21 interacts with IL-4 to regulate GC responses and its role in autoimmune responses. The second article explores a new induction system that enhances the generation of human macrophages from induced pluripotent stem cells (iPSCs), which can be used for therapeutic purposes. The third article focuses on the transcription factor Nurr1 and its involvement in macrophage polarization and inflammatory responses. The authors examine Nurr1 expression and activity in different types of macrophages and show that Nurr1 activation suppresses inflammatory and cytotoxic responses. The final article investigates the role of acetyl-CoA carboxylase 1 (ACC1) in the development of invariant NKT (iNKT) cells. The authors demonstrate that ACC1 is essential for early thymic iNKT cell development and mediates their survival by controlling mitochondrial activity.
- Subjects
BULLOUS pemphigoid; AUTOIMMUNE diseases; INDUCED pluripotent stem cells; B cell differentiation
- Publication
International Immunology, 2024, Vol 36, Issue 3, p87
- ISSN
0953-8178
- Publication type
Article
- DOI
10.1093/intimm/dxae004