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- Title
Comprehensive profiling of H-Ras signalling in angiosarcoma endothelium.
- Authors
Costa, A.; Bonner, M.; Arbiser, J. L.
- Abstract
The MS1/ SVR system, in which MS1 represents immortalized endothelial cells and SVR represents MS1 cells transformed with oncogenic human-rat sarcoma protein (H-Ras), has been used for around 20 years as a valuable tool to study angiogenesis and carcinogenesis. Despite the use of these cells in numerous studies, a comprehensive profile of the signalling differences due to oncogenic H-Ras transformation has not been performed previously. In this study, we profiled the well-known MS1 and SVR cell lines using a combination of both Western blot and gene chip assays.
- Subjects
HRAS genes; ANGIOSARCOMA; ENDOTHELIUM diseases; ENDOTHELIAL cells; ONCOGENIC viruses; CELL lines
- Publication
Clinical & Experimental Dermatology, 2017, Vol 42, Issue 6, p645
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1111/ced.13149