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- Title
Towards a unified open access dataset of molecular interactions.
- Authors
Porras, Pablo; Barrera, Elisabet; Bridge, Alan; del-Toro, Noemi; Cesareni, Gianni; Duesbury, Margaret; Hermjakob, Henning; Iannuccelli, Marta; Jurisica, Igor; Kotlyar, Max; Licata, Luana; Lovering, Ruth C.; Lynn, David J.; Meldal, Birgit; Nanduri, Bindu; Paneerselvam, Kalpana; Panni, Simona; Pastrello, Chiara; Pellegrini, Matteo; Perfetto, Livia
- Abstract
The International Molecular Exchange (IMEx) Consortium provides scientists with a single body of experimentally verified protein interactions curated in rich contextual detail to an internationally agreed standard. In this update to the work of the IMEx Consortium, we discuss how this initiative has been working in practice, how it has ensured database sustainability, and how it is meeting emerging annotation challenges through the introduction of new interactor types and data formats. Additionally, we provide examples of how IMEx data are being used by biomedical researchers and integrated in other bioinformatic tools and resources. The IMEx consortium provides one of the largest resources of curated, experimentally verified molecular interaction data. Here, the authors review how IMEx evolved into a fundamental resource for life scientists and describe how IMEx data can support biomedical research.
- Subjects
MOLECULAR interactions; PROTEIN-protein interactions; SCIENTISTS; CONSORTIA
- Publication
Nature Communications, 2020, Vol 11, Issue 1, pN.PAG
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-020-19942-z