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- Title
Deuterium isotope effect on the suicide inactivation of tyrosinase in its action on o-diphenols.
- Authors
Muñoz‐Muñoz, Jose Luis; del Mar García‐Molina, María; Garcia‐Molina, Francisco; Garcia‐Ruiz, Pedro Antonio; Garcia‐Sevilla, Francisco; Rodriguez‐Lopez, Jose N.; Garcia‐Canovas, Francisco
- Abstract
A solvent deuterium isotope effect on the inactivation suicide of tyrosinase in its action on o-diphenols (catechol, 4-methylcatechol, and 4-tert-butylcatechol) was observed. This isotope effect, observed during kinetic studies in the transition phase, was higher than that described previously in the steady state, indicating that there is an additional slow step in the suicide inactivation mechanism, which we believe to be responsible for the inactivation. In a proton inventory study of oxidation of o-diphenols, the representation of
- Subjects
DEUTERIUM; SUICIDE; PHENOL oxidase; PROTONS; OXIDATION
- Publication
IUBMB Life, 2013, Vol 65, Issue 9, p793
- ISSN
1521-6543
- Publication type
Article
- DOI
10.1002/iub.1191