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- Title
Quality of life and long-term outcomes after hospitalization for COVID-19: Protocol for a prospective cohort study (Coalition VII).
- Authors
Goulart Rosa, Regis; Cabral Robinson, Caroline; Cordeiro Veiga, Viviane; Biasi Cavalcanti, Alexandre; Pontes de Azevedo, Luciano César; Ribeiro Machado, Flávia; Berwanger7Avezum, Otavio Álvaro; Delascio Lopes, Renato; Costa Lisboa, Thiago; Teixeira, Cassiano; Godinho Zampieri, Fernando; Martins Tomazini, Bruno; Kawano-Dourado, Letícia; Schneider, Daniel; de Souza, Denise; da Rosa Minho dos Santos, Rosa; Souza da Silva, Sabrina; Trott, Geraldine; dos Passos Gimenes, Bruna; Paula de Souza, Ana
- Abstract
Introduction: The long-term effects caused by COVID-19 are unknown. The present study aims to assess factors associated with health-related quality of life and long-term outcomes among survivors of hospitalization for COVID-19 in Brazil. Methods: This is a multicenter prospective cohort study nested in five randomized clinical trials designed to assess the effects of specific COVID-19 treatments in over 50 centers in Brazil. Adult survivors of hospitalization due to proven or suspected SARS-CoV-2 infection will be followed-up for a period of 1 year by means of structured telephone interviews. The primary outcome is the 1-year utility score of health-related quality of life assessed by the EuroQol-5D3L. Secondary outcomes include allcause mortality, major cardiovascular events, rehospitalizations, return to work or study, physical functional status assessed by the Lawton-Brody Instrumental Activities of Daily Living, dyspnea assessed by the modified Medical Research Council dyspnea scale, need for long-term ventilatory support, symptoms of anxiety and depression assessed by the Hospital Anxiety and Depression Scale, symptoms of posttraumatic stress disorder assessed by the Impact of Event Scale-Revised, and self-rated health assessed by the EuroQol-5D3L Visual Analog Scale. Generalized estimated equations will be performed to test the association between five sets of variables (1- demographic characteristics, 2- premorbid state of health, 3- characteristics of acute illness, 4- specific COVID-19 treatments received, and 5- time-updated postdischarge variables) and outcomes. Ethics and dissemination: The study protocol was approved by the Research Ethics Committee of all participant institutions. The results will be disseminated through conferences and peer-reviewed journals.
- Subjects
COVID-19 testing; QUALITY of life; PATIENT reported outcome measures
- Publication
Revista Brasileira de Terapia Intensiva, 2021, Vol 33, Issue 1, p31
- ISSN
0103-507X
- Publication type
Article
- DOI
10.5935/0103-507X.20210003