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- Title
Age and Non-Communicable Disease Related Observations in the Wall of Arteries of Lower Extremities and Their Histomorphometric and Immunohistochemical Analysis.
- Authors
Nelluri, Venumadhav; Rao, T. Ramesh; S, Sudarshan; R, Deepthinath; K, Anjaneyulu
- Abstract
Aim and Objectives: Arteries of the lower extremities are more prone to disease conditions such as atherosclerosis. The atheromatous changes in their wall could block or reduce the blood flow that leads to conditions like claudication. Changes due to age or non-communicable diseases mostly affect the femoral, popliteal, anterior and posterior tibial arteries. In this study, the histomorphometric changes in the walls of the above-mentioned arteries have been analyzed. Materials and methods: Arterial samples of the above-mentioned arteries were collected from 50 cadavers, aged over 19 years and from them, the proximal, middle and distal segments were collected. Based on age, the samples were divided into the following groups; between 19 - 40 years into Group1, 41 - 60 years into Group 2, 61 years & above as Group 3, Hypertension Group into 'H' and Diabetic Group as 'D'. Arterial samples were processed for histological procedures then analysed for the histomorphometric changes. Results: The histomorphometric analysis revealed a prominent decrease in elastic fibres and smooth muscles in the tunica media and intima, along with hyperplasia and luminal size reduction.
- Subjects
TIBIAL arteries; AGE factors in disease; LEG; NON-communicable diseases; ARTERIES
- Publication
Journal of the Indian Academy of Geriatrics, 2019, Vol 15, Issue 4, p203
- ISSN
0974-3405
- Publication type
Article