We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Recent Progress in Therapeutic Treatments and Screening Strategies for the Prevention and Treatment of HPV-Associated Head and Neck Cancer.
- Authors
Whang, Sonia N.; Filippova, Maria; Duerksen-Hughes, Penelope
- Abstract
The rise in human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) has elicited significant interest in the role of high-risk HPV in tumorigenesis. Because patients with HPV-positive HNSCC have better prognoses than do their HPV-negative counterparts, current therapeutic strategies for HPV+ HNSCC are increasingly considered to be overly aggressive, highlighting a need for customized treatment guidelines for this cohort. Additional issues include the unmet need for a reliable screening strategy for HNSCC, as well as the ongoing assessment of the efficacy of prophylactic vaccines for the prevention of HPV infections in the head and neck regions. This review also outlines a number of emerging prospects for therapeutic vaccines, as well as for targeted, molecular-based therapies for HPV-associated head and neck cancers. Overall, the future for developing novel and effective therapeutic agents for HPV-associated head and neck tumors is promising; continued progress is critical in order to meet the challenges posed by the growing epidemic.
- Subjects
ONCOGENIC DNA viruses; PAPILLOMAVIRUS diseases; HEAD &; neck cancer; SQUAMOUS cell carcinoma
- Publication
Viruses (1999-4915), 2015, Vol 7, Issue 9, p5040
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v7092860