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- Title
Role of Polycomb Proteins in Regulating HSV-1 Latency.
- Authors
Watson, Zachary; Dhummakupt, Adit; Messer, Harald; Phelan, Dane; Bloom, David
- Abstract
Herpes simplex virus (HSV) establishes a latent infection within sensory neurons of humans. Latency is characterized by the transcriptional repression of lytic genes by the condensation of lytic gene regions into heterochromatin. Recent data suggest that facultative heterochromatin predominates, and that cellular Polycomb proteins are involved in the establishment and maintenance of transcriptional repression during latency. This review summarizes these data and discusses the implication of viral and cellular factors in regulating heterochromatin composition.
- Subjects
HERPES simplex; HERPESVIRUS genetics; POLYCOMB group protein genetics; PROTEIN genetics; GENETICS of virus diseases; GENETICS
- Publication
Viruses (1999-4915), 2013, Vol 5, Issue 7, p1740
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v5071740