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- Title
No significant effect of acute moderate alcohol intake on leptin levels in healthy male volunteers.
- Authors
Dammann, Gerhard; Dierkes, Jutta; Graf, Marc; Wiesbeck, Gerhard A.; Pridzun, Lutz; Schulte, Tilman; Westphal, Sabine; Luley, Claus; Allen, John P.; Wurst, Friedrich Martin
- Abstract
As, for ethical reasons, it is difficult to investigate by an experiment the effect of acute intoxication on leptin levels in alcoholics, we tested the hypothesis of lowered levels as an effect of acute ethanol intake in healthy volunteers. The subjects comprised (1) 17 healthy male participants, recruited via newspaper advertisements [age 29 ± 3.75 years, body mass index (BMI) 24.3 ± 3.5, leptin at baseline 3.3 ± 3.1 ng/ml]; (2) for comparison, leptin levels of 16 male alcoholic patients at day 1 of withdrawal were used. They were characterized as follows: (mean, median, standard deviation and range) age in years (41.1, 40.5, 10.2, 24, 57), BMI (23.3, 21.7, 5.4, 16.6, 37.5), 1032 g of ethanol (median) consumed within the last 7 days, leptin levels 2.3 mg/ml. A placebo-controlled double-blind trial was performed. Leptin levels of blood samples were taken at baseline ( t 1 ), before ethanol intake ( t 2 ), when blood alcohol had reached its maximum ( t 3 ) and the morning after ( t 4 ). The oral dose of ethanol administered was 0.6 g/kg ethanol. (1) Volunteers: (a) the ethanol and placebo group exhibited leptin levels corresponding closely with levels measured at baseline ( t 1 ) ( r s = 0.85, p
- Subjects
ALCOHOLISM; SUBSTANCE abuse; ALCOHOL; PEOPLE with alcoholism; LEPTIN; HORMONES; MALES; ALCOHOL in the body
- Publication
Addiction Biology, 2005, Vol 10, Issue 4, p357
- ISSN
1355-6215
- Publication type
Article
- DOI
10.1080/13556210500313875