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- Title
The Use of Nonoxyl-9 for Protection Against Cervical Gonorrhea.
- Authors
Weir, Sharon S.; Feldblum, Paul J.; Zekeng, Leopold; Roddy, Ronald E.
- Abstract
Objectives. Although condoms are the best defense against sexually transmitted disease, little is known about the effectiveness of female-controlled methods containing nonoxynol-9 as backup protection when condoms are not being used. Methods. To assess the extent to which nonoxynol-9 protects women against gonorrhea, a cohort of 303 female sex workers (prostitutes) in yaounde, Cameroon, were asked to use condoms and suppositories containing nonoxynol-9 at every sexual encounter and to record daily sexual activity and use of condoms and suppositories on coital logs that were reviewed monthly. Evidence of gonorrheal infection was based on a positive gorirrhea culture. Stratified analysis and proportional hazards regression were used to estimate rate ratios. Results. Forty-one women enrolled in the study were excluded from the current analysis. The estimated incidence of gonorrhea was 6.2 infections per 100 person-months of observation. Incidence rate ratios estimated from proportional hazards regression models controlling for condom use showed that using non-oxynol-9 during acts not protected by condoms reduced the risk of infection. Conclusions. Although the protective effect of condoms against sexually transmitted disease is greater than that afforded by nonoxynol-9, using nonoxynol-9 when condoms are not used is a far better strategy in gonorrhea prevention than using no method at all.
- Subjects
CAMEROON; CONDOMS; PREVENTION of sexually transmitted diseases; NONOXYNOL-9; GONORRHEA; SEX workers
- Publication
American Journal of Public Health, 1994, Vol 84, Issue 6, p910
- ISSN
0090-0036
- Publication type
Article
- DOI
10.2105/AJPH.84.6.910