We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
CNS pathogenesis of prion diseases.
- Authors
Sebastian Brandner
- Abstract
Prion diseases or transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases, clinically characterised by cognitive decline, paralleled by severe damage to the central nervous system. Prion diseases have attracted a broad interest because of their unique mechanisms of replication and propagation; however, the underlying pathogenic mechanisms are still highly speculative. In this review, current knowledge about the pathogenesis of prion diseases in the CNS will be highlighted and the most revealing animal models will be discussed, with future perspectives to address immediate questions about the pathogenesis.
- Subjects
NEURODEGENERATION; HEPATIC encephalopathy; CENTRAL nervous system; ANIMAL models in research
- Publication
British Medical Bulletin, 2003, Vol 66, Issue 1, p131
- ISSN
0007-1420
- Publication type
Article
- DOI
10.1093/bmb/66.1.131