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- Title
Cytotoxic Biflavonoids from Selaginella braunii.
- Authors
Liu, Xue-Feng; Fu, Tong-Fei; Wu, Jun-Song; Lu, Bi-Chao; Zhang, Ping; Liu, He-Jing
- Abstract
A new biflavonoid, (2″ S)-8″-C-methyl-2″,3″-dihydrorobustaflavone-4′-methyl ether (1) and 5 known robustaflavones (2 - 6) were isolated from the 70% EtOH extract of Selaginella braunii for the first time. The structures of 1 and the known compounds were identified by performing a comprehensive analysis of spectroscopic data including ultraviolet-visible, high-resolution electrospray ionization mass spectrometry, 1-dimensional and 2-dimensional nuclear magnetic resonance, and circular dichroism spectra. Compounds 1 - 6 were determined for cytotoxic activity against 3 human cancer cell lines (SMMC-7721, MCF-7, and A549). Compound 1 exerted apparent antiproliferative effects on SMMC-7721, MCF-7, and A549 cells, with IC50 values of 18.6, 16.7, and 25.5 μM, respectively.
- Subjects
ULTRAVIOLET spectrometry; ELECTROSPRAY ionization mass spectrometry; SELAGINELLA; NUCLEAR magnetic resonance; CIRCULAR dichroism
- Publication
Natural Product Communications, 2022, Vol 17, Issue 9, p1
- ISSN
1934-578X
- Publication type
Article
- DOI
10.1177/1934578X221125056