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- Title
The clinical and biological features of a series of immunophenotypic variant of B-CLL.
- Authors
Cro, Lilla; Ferrario, Andrea; Lionetti, Marta; Bertoni, Francesco; Zucal N, Nadia; Nobili, Lucia; Fabris, Sonia; Todoerti, Katia; Cortelezzi, Agostino; Guffanti, Andrea; Goldaniga, Maria; Marcheselli, Luigi; Neri, Antonino; Lambertenghi-Deliliers, Giorgio; Baldini, Luca
- Abstract
Objectives: To describe the clinical and biological features of a series of immunophenotypic variant of B-CLL (v-CLL) characterised by intermediate RMH score, in the absence of t(11;14)(q13;q32) in FISH analysis in comparison with a series of typical CLL. Methods: We studied the clinical and biological features of 63 cases of v-CLL and 130 cases of CLL. Results: We observed significant differences in terms of age <70 yr ( P < 0.001), lymphocytosis <20 × 109/L ( P < 0.001), lymphocyte doubling time ≤12 months ( P = 0.02), high serum β2-microglobulin levels ( P < 0.001) and splenomegaly ( P = 0.002); CD38, CD49d, CD1c were more expressed in v-CLL, CD43 in CLL ( P < 0.001). IgVH mutation and trisomy 12 were more frequent in v-CLL group ( P = 0.001; P < 0.001); del13q14 in CLL ( P = 0.008). Gene expression profiling of nine v-CLL and 60 CLL indicated that the atypical group presented a specific molecular pattern. After a median follow-up of respectively, 55 (4–196) and 60 months (6–180), 25/42 patients with v-CLL (48%) and 55/93 patients with CLL (59%) were treated. Time to treatment was significantly shorter in IgVH-mutated v-CLL vs. mutated CLL ( P = 0.006). The median overall survival was worse in v-CLL-mutated cases ( P = 0.062). Conclusion: v-CLL should be identified and dealt with separately from classic CLL. In particular, the prognostic markers that are routinely used to characterise classical B-CLL should not be interpreted as having the same meaning.
- Subjects
CHRONIC lymphocytic leukemia; FLUORESCENCE in situ hybridization; TRISOMY; CHROMOSOME abnormalities; BIOMARKERS
- Publication
European Journal of Haematology, 2010, Vol 85, Issue 2, p120
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/j.1600-0609.2010.01454.x