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- Title
Role of IKK/NF-κB Signaling in Extinction of Conditioned Place Aversion Memory in Rats.
- Authors
Cheng-Hao Yang; Xiang-Ming Liu; Ji-Jian Si; Hai-Shui Shi; Yan-Xue Xue; Jian-Feng Liu; Yi- Xiao Luo; Chen Chen; Peng Li; Jian-Li Yang; Ping Wu; Lin Lu
- Abstract
The inhibitor kB protein kinase/nuclear factor kB (IKK/NF-kB) signaling pathway is critical for synaptic plasticity. However, the role of IKK/NF-kB in drug withdrawal-associated conditioned place aversion (CPA) memory is unknown. Here, we showed that inhibition of IKK/NF-kB by sulphasalazine (SSZ; 10 mM, i.c.v.) selectively blocked the extinction but not acquisition or expression of morphine-induced CPA in rats. The blockade of CPA extinction induced by SSZ was abolished by sodium butyrate, an inhibitor of histone deacetylase. Thus, the IKK/NF-kB signaling pathway might play a critical role in the extinction of morphine-induced CPA in rats and might be a potential pharmacotherapy target for opiate addiction.
- Subjects
PROTEIN kinases; NF-kappa B; NEUROPLASTICITY; DRUG withdrawal symptoms; MORPHINE; LABORATORY rats
- Publication
PLoS ONE, 2012, Vol 7, Issue 6, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0039696