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- Title
Fibrosis in diabetes complications: Pathogenic mechanisms and circulating and urinary markers.
- Authors
Ban, Camelia R.; Twigg, Stephen M.
- Abstract
Diabetes mellitus is characterized by a lack of insulin causing elevated blood glucose, often with associated insulin resistance. Over time, especially in genetically susceptible individuals, such chronic hyperglycemia can cause tissue injury. One pathological response to tissue injury is the development of fibrosis, which involves predominant extracellular matrix (ECM) accumulation. The main factors that regulate ECM in diabetes are thought to be pro-sclerotic cytokines and protease/anti-protease systems. This review will examine the key markers and regulators of tissue fibrosis in diabetes and whether their levels in biological fluids may have clinical utility.
- Publication
Vascular Health & Risk Management, 2008, Vol 4, Issue 3, p575
- ISSN
1176-6344
- Publication type
Article