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- Title
Molecular Profiling Reveals Prognostically Significant Subtypes of Canine Lymphoma.
- Authors
Frantz, A. M.; Sarver, A. L.; Ito, D.; Phang, T. L.; Karimpour-Fard, A.; Scott, M. C.; Valli, V. E. O.; Lindblad-Toh, K.; Burgess, K. E.; Husbands, B. D.; Henson, M. S.; Borgatti, A.; Kisseberth, W. C.; Hunter, L. E.; Breen, M.; O’Brien, T. D.; Modiano, J. F.
- Abstract
We performed genomewide gene expression analysis of 35 samples representing 6 common histologic subtypes of canine lymphoma and bioinformatics analyses to define their molecular characteristics. Three major groups were defined on the basis of gene expression profiles: (1) low-grade T-cell lymphoma, composed entirely by T-zone lymphoma; (2) high-grade T-cell lymphoma, consisting of lymphoblastic T-cell lymphoma and peripheral T-cell lymphoma not otherwise specified; and (3) B-cell lymphoma, consisting of marginal B-cell lymphoma, diffuse large B-cell lymphoma, and Burkitt lymphoma. Interspecies comparative analyses of gene expression profiles also showed that marginal B-cell lymphoma and diffuse large B-cell lymphoma in dogs and humans might represent a continuum of disease with similar drivers. The classification of these diverse tumors into 3 subgroups was prognostically significant, as the groups were directly correlated with event-free survival. Finally, we developed a benchtop diagnostic test based on expression of 4 genes that can robustly classify canine lymphomas into one of these 3 subgroups, enabling a direct clinical application for our results.
- Subjects
T-cell lymphoma; LYMPHOMA diagnosis; BIOINFORMATICS; GENE expression; HISTOPATHOLOGY
- Publication
Veterinary Pathology, 2013, Vol 50, Issue 4, p693
- ISSN
0300-9858
- Publication type
Article
- DOI
10.1177/0300985812465325