We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Urinary PSA level and relative tumor volume after prostate biopsy.
- Authors
Pejčić, T.; Hadži-Djokić, J.; Marković, B.; Dragićević, D.; Gliš, B.; Lalić, N.; Aćimović, M.; Džamić, Z.; Radosavljevic, R.
- Abstract
Objectives: To estimate the ratio between urinary prostate specific antigen (uPSA) and tumor volume after prostate biopsy. Methods: From 2000 to July 2008, uPSA concentration was determined in 60 patients with clinically organ-confined prostate cancer (PCa). All patients underwent six-area transrectal ultrasound (TRUS) - guided biopsy, with at least 12 biopsy cores. Single pathologist determined tumor grade (C), Gleason score (CS), the percentage of tutuor infiltration (% TI) and the percentage of positive cores (% PC) in all biopsy cores. Additionally, relative tumor-biopsy volume (RTV) was calculated by multiplying % PC, % TI and prostate ultra- sound-derived volume (Vol). Forty-one patients underwent retropubic radical prostatectomy (RRP), while 19 patients underwent radiation therapy. Results: Average uPSA was 308.6±311.9 ng/ml (range 0.06-988 ng/ml), average PSA was 9.7± 5.5 ng/ml (range 1.2-24.3 ng/ml), tumor grade 1.7± 0.8, Gleason score 5.2 ± 1.3, the percentage of tumor infiltration 27.6±21.8 %, and the percentage of positive cores, 52.2±30.7 %. Average RTV was 6.3± 8.4 ml (0.29-56 ml). All patients were divided in two groups: I, with RTV 4 ml and H, with RTV 4 ml. The patients with RTV 4 ml had lower G(1.4 0.6 vs. 2.1±0.8, p0.0002), lower CS (4.5±1 vs. 5.8±1.3, p=0.003) and higher uPSA (389.4±340.8 vs. 1931±229.7, p=0.014). There were no differences in serum PSA levels between the groups. Conclusion: Relative tumor-biopsy volume (RTV) is useful parameter in the preoperative assessment of tumor volume. Patients with higher RTV had significantly higher C and CS. However, these patients had significantly lower uPSA. This phenomenon could be the consequence of compromised PSA drainage from the peripheral zone of the prostate, caused by the tumor.
- Subjects
PROSTATE cancer; BIOPSY; MEDICAL imaging systems; ANTIGENS; PROSTATE cancer patients; TUMOR diagnosis
- Publication
Acta Chirurgica Iugoslavica, 2009, Vol 56, Issue 2, p17
- ISSN
0354-950X
- Publication type
Article
- DOI
10.2298/ACI0902017P