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- Title
Intranasal Influenza Vaccine in a Working Population.
- Authors
Sendi, Pedram; Locher, Rebecca; Bucheli, Bruno; Battegay, Manuel
- Abstract
In the present study, we assessed the incidence of adverse events and influenza-like symptoms in a working population in Switzerland that was vaccinated against influenza. A total of 12,582 individuals of working age (<65 years old) were offered a free influenza vaccine of their choice (injectable or intranasal vaccine) in October and November 2000. Of these individuals, 1600 were vaccinated against influenza. Ninety-seven percent of the vaccine recipients chose the intranasal vaccine, and 3% chose the injectable influenza vaccine. The incidence of influenza-like symptoms and side effects was 13% and 36%, respectively. Individuals who chose the intranasal vaccine were more likely to report side effects (OR, 3.23; 95% CI, 1.29-8.08). Facial paralysis was observed in 11 patients and was the most severe adverse event associated with the intranasal influenza vaccine. As a result of these adverse events, the intranasal vaccine was removed from the market in the fall of 2001.
- Subjects
SWITZERLAND; INFLUENZA; INFLUENZA vaccines; INTRANASAL medication; FACIAL paralysis; DRUG side effects
- Publication
Clinical Infectious Diseases, 2004, Vol 38, Issue 7, p974
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/386330