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- Title
Indinavir-Associated Interstitial Nephritis and Urothelial Inflammation: Clinical and Cytologic Findings.
- Authors
Kopp, Jeffrey B.; Falloon, Judith; Filie, Armando; Abati, Andrea; King, Christine; Hortin, Glen L.; Mican, JoAnn M.; Vaughan, Ellen; Miller, Kirk D.
- Abstract
The objective of the present study was to characterize the genitourinary syndromes that accompany indinavir-associated pyuria. Of 23 indinavir-treated patients with persistent pyuria, 4 had isolated interstitial nephritis, 10 had both interstitial nephritis and urothelial inflammation, 7 had isolated urothelial inflammation, and 2 had pyuria with nonspecific urinary tract inflammation. A total of 21 patients had multinucleated histiocytes identified by cytologic testing of urine specimens. Urine abnormalities resolved in all 20 patients who stopped receiving indinavir therapy. Pyuria continued in the 3 patients who continued receiving indinavir. Six patients had elevated serum creatinine levels, which returned to baseline levels when indinavir was discontinued. In conclusion, indinavir-associated pyuria was frequently associated with evidence of interstitial nephritis and/or urothelial inflammation, multinucleated histiocytes were commonly present in urine specimens, and cessation of indinavir therapy was associated with prompt resolution of urine abnormalities.
- Subjects
INTERSTITIAL nephritis; GENITOURINARY diseases
- Publication
Clinical Infectious Diseases, 2002, Vol 34, Issue 8, p1122
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/339486