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- Title
Searching for evidence in neonatology.
- Authors
Saugstad, Ola Didrik; Kirpalani, Haresh
- Abstract
Evidence‐based medicine has changed clinical practice by incorporating data from randomised controlled trials (RCTs). While some biases in RCTs are well recognised, we discuss some less acknowledged. Selection bias may arise in the consent stage. Industry‐funded studies more often report a positive outcome. Post‐hoc changes of outcome measures and other mis‐reporting lowers the reliability of outcome data. Finally, even the GRADE system retains subjectivity. Conclusion: Moving from "intuition" into "evidence‐based" medicine involves grappling with several pitfalls. These pose challenges for authors, editors, reviewers, and readers. All require vigilance before drawing conclusions from presented data.
- Subjects
NEONATOLOGY; EVIDENCE-based medicine; RANDOMIZED controlled trials
- Publication
Acta Paediatrica, 2023, Vol 112, Issue 8, p1648
- ISSN
0803-5253
- Publication type
Article
- DOI
10.1111/apa.16815