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- Title
Anti-mycobacterial activities of copper(II) complexes. Part II. Lipophilic hydroxypyridinones derived from maltol.
- Authors
Salsbury, Lauren E.; Robertson, Katherine N.; Flewelling, Andrew J.; Li, Hoaxin; Geier, Stephen J.; Vogels, Christopher M.; Gray, Christopher A.; Westcott, Stephen A.
- Abstract
Eight lipophilic 3-hydroxy-4-pyridinones have been prepared from a microwave-mediated reaction along with the corresponding copper(II) complexes. All complexes have been obtained elementally pure and X-ray diffraction studies on two of the copper complexes have confirmed the structure of these compounds. Some of these complexes showed a promising degree of anti-mycobacterial activity against Mycobacterium tuberculosis, where activity seemed to vary by substitution at the pyridinone nitrogen atom.
- Subjects
MYCOBACTERIUM tuberculosis; METAL complexes; ANTIBACTERIAL agents; LIPOPHILICITY; PYRIDONE derivatives; ORGANIC compounds; X-ray diffraction; THERAPEUTICS
- Publication
Canadian Journal of Chemistry, 2015, Vol 93, Issue 3, p334
- ISSN
0008-4042
- Publication type
Article
- DOI
10.1139/cjc-2014-0426