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- Title
Craniosynostosis-Associated Gene Nell-1 Is Regulated by Runx2.
- Authors
Thien Truong; Xinli Zhang; Pathmanathan, Dharmini; Chia Soo; Kang Ting
- Abstract
The article reports on the study about the transcriptional regulation of NELL-1, a craniosynostosis-related gene. Researchers have identified three osteoblast specific binding element 2 (OSE2) in the NELL-1 promoter that are directly bound and transactivated by Runx2. They found that Runx2 directly binds to the OSE2 elements and transactivates the human NELL-1 promoter. The finding are essential in understanding the molecular mechanisms governing the pathogenesis of craniosynostosis.
- Subjects
PROMOTERS (Genetics); GENETIC transcription; CRANIOSYNOSTOSES; CRANIAL sutures; SKULL abnormalities
- Publication
Journal of Bone & Mineral Research, 2007, Vol 22, Issue 1, p7
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1359/JBMR.061012