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- Title
Comparison of an exact and a simulation method for calculating gene extinction probabilities in pedigrees.
- Authors
Thomas, Alun
- Abstract
A comparison is made between a much used simulation method, commonly called gene dropping, and the exact computational technique of peeling. These methods are illustrated using the problem of finding the distribution of the number of distinct ancestral genes surviving at an autosomal locus. Each method is used on several real zoo pedigrees, of varying size and complexity, and the results are compared. Gene dropping is found to be a good approximation to peeling, but for all but the most complex pedigrees surveyed, peeling is preferable. The relationship between heterozygosity and allelic variability is investigated.
- Publication
Zoo Biology, 1990, Vol 9, Issue 4, p259
- ISSN
0733-3188
- Publication type
Article
- DOI
10.1002/zoo.1430090402