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- Title
Analiza antiapoptotskog proteina bcl-2 u skvamocelularnom karcinomu usne regije.
- Authors
Popović, Branka; Jekić, Biljana; Novaković, Ivana; Milašin, Jelena
- Abstract
Aim: The aim of this study was to analyze the presence of the anti-apoptotic protein bcl-2 in oral squamous cell carcinoma and determine its potential role in the development and progressioin of this type of tumor. Materials and methods: The expression of bcl-2 was determined in 28 paraffin blocks of oral squamous cell carcinoma using the immunohistochemical method. The percentage of the immuno-reactive cells in positively stained tumor regions was determined using the microscopic analysis and Ozaria software. Results: Positive immunohistochemical test was observed in 19 out of 28 samples (68%) as follows: in 11 samples there was a low (+), in four a moderate (++) and in the last four a high percentage (+++) of stained cells. In the group of patients at the low stage of the disease (T2), 50% of tumor samples showed bcl-2 protein expression whereas in the higher stages (T3 and T4) of positively stained samples, this percentage was 67%. There was a trend of an increasing number of cells with positive bcl-2 staining in the tumors of higher clinical stages but not the level of bcl-2 protein expression. Conclusion: Both parameters, the presence of bcl-2 staining and the percentage of cells with bcl-2 immunoexpression, may act as additional prognostic parameters that indicate an increased proliferative tumor potential.
- Subjects
SQUAMOUS cell carcinoma; IMMUNOHISTOCHEMISTRY techniques; CELLS; METALLOGRAPHY; CANCER patients
- Publication
Serbian Dental Journal / Stomatološki Glasnik Srbije, 2007, Vol 54, Issue 3, p153
- ISSN
0039-1743
- Publication type
Article
- DOI
10.2298/SGS0703153P