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- Title
Pulmonary arterial hypertension associated with interferon beta treatment for multiple sclerosis: a case report.
- Authors
Ledinek, A.H.; Jazbec, S.Š.; Drinovec, I.; Rot, U.
- Abstract
A 23-year-old woman with multiple sclerosis developed respiratory symptoms 3 years after introduction of interferon beta-1b. The diagnosis of pulmonary arterial hypertension (PAH) was established. The patient partially responded to sildenafil and bosetan treatment. This is the first report of PAH, associated with interferon beta therapy. As shown in experimental models, interferon treatment can induce PAH by stimulation of thromboxane cascade and secretion of various inflammatory mediators.
- Subjects
PULMONARY hypertension; CARDIOVASCULAR diseases; ANTINEOPLASTIC agents; ANTIVIRAL agents; MULTIPLE sclerosis; GLYCOPROTEINS
- Publication
Multiple Sclerosis (13524585), 2009, Vol 15, Issue 7, p885
- ISSN
1352-4585
- Publication type
Case Study
- DOI
10.1177/1352458509104593