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Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32958-x
By:
- Freckmann, Eva C.;
- Sandilands, Emma;
- Cumming, Erin;
- Neilson, Matthew;
- Román-Fernández, Alvaro;
- Nikolatou, Konstantina;
- Nacke, Marisa;
- Lannagan, Tamsin R. M.;
- Hedley, Ann;
- Strachan, David;
- Salji, Mark;
- Morton, Jennifer P.;
- McGarry, Lynn;
- Leung, Hing Y.;
- Sansom, Owen J.;
- Miller, Crispin J.;
- Bryant, David M.
Publication type:
Article
ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth.
Published in:
EMBO Molecular Medicine, 2017, v. 9, n. 2, p. 198, doi. 10.15252/emmm.201606743
By:
- Rath, Nicola;
- Morton, Jennifer P;
- Julian, Linda;
- Helbig, Lena;
- Kadir, Shereen;
- McGhee, Ewan J;
- Anderson, Kurt I;
- Kalna, Gabriela;
- Mullin, Margaret;
- Pinho, Andreia V;
- Rooman, Ilse;
- Samuel, Michael S;
- Olson, Michael F
Publication type:
Article
Targeting the LOX/ hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.
Published in:
EMBO Molecular Medicine, 2015, v. 7, n. 8, p. 1063, doi. 10.15252/emmm.201404827
By:
- Miller, Bryan W;
- Morton, Jennifer P;
- Pinese, Mark;
- Saturno, Grazia;
- Jamieson, Nigel B;
- McGhee, Ewan;
- Timpson, Paul;
- Leach, Joshua;
- McGarry, Lynn;
- Shanks, Emma;
- Bailey, Peter;
- Chang, David;
- Oien, Karin;
- Karim, Saadia;
- Au, Amy;
- Steele, Colin;
- Carter, Christopher Ross;
- McKay, Colin;
- Anderson, Kurt;
- Evans, Thomas R Jeffry
Publication type:
Article
The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy.
Published in:
Journal of Pathology, 2019, v. 249, n. 3, p. 332, doi. 10.1002/path.5320
By:
- Reader, Claire S;
- Vallath, Sabari;
- Steele, Colin W;
- Haider, Syed;
- Brentnall, Adam;
- Desai, Ami;
- Moore, Kate M;
- Jamieson, Nigel B;
- Chang, David;
- Bailey, Peter;
- Scarpa, Aldo;
- Lawlor, Rita;
- Chelala, Claude;
- Keyse, Stephen M;
- Biankin, Andrew;
- Morton, Jennifer P;
- Evans, TR Jeffry;
- Barry, Simon T;
- Sansom, Owen J;
- Kocher, Hemant M
Publication type:
Article
CXCR2 inhibition suppresses acute and chronic pancreatic inflammation.
Published in:
Journal of Pathology, 2015, v. 237, n. 1, p. 85, doi. 10.1002/path.4555
By:
- Steele, Colin W;
- Karim, Saadia A;
- Foth, Mona;
- Rishi, Loveena;
- Leach, Joshua DG;
- Porter, Ross J;
- Nixon, Colin;
- Jeffry Evans, TR;
- Carter, C Ross;
- Nibbs, Robert JB;
- Sansom, Owen J;
- Morton, Jennifer P
Publication type:
Article
Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.
Published in:
2014
By:
- Arjonen, Antti;
- Kaukonen, Riina;
- Mattila, Elina;
- Rouhi, Pegah;
- Högnäs, Gunilla;
- Sihto, Harri;
- Miller, Bryan W;
- Morton, Jennifer P;
- Bucher, Elmar;
- Taimen, Pekka;
- Virtakoivu, Reetta;
- Cao, Yihai;
- Sansom, Owen J;
- Joensuu, Heikki;
- Ivaska, Johanna
Publication type:
journal article
Mutant p53--associated myosin-X upregulation promotes breast cancer invasion and metastasis.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 3, p. 1069, doi. 10.1172/JCI67280
By:
- Arjonen, Antti;
- Kaukonen, Riina;
- Mattila, Elina;
- Rouhi, Pegah;
- Högnäs, Gunilla;
- Harri Sihto;
- Miller, Bryan W.;
- Morton, Jennifer P.;
- Bucher, Elmar;
- Taimen, Pekka;
- Virtakoivu, Reetta;
- Yihai Cao;
- Sansom, Owen J.;
- Joensuu, Heikki;
- Ivaska, Johanna
Publication type:
Article
RNA polymerase III transcription is repressed in response to the tumour suppressor ARF.
Published in:
Nucleic Acids Research, 2007, v. 35, n. 9, p. 3046, doi. 10.1093/nar/gkm208
By:
- Morton, Jennifer P.;
- Kantidakis, Theodoros;
- White, Robert J.
Publication type:
Article
Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23731-7
By:
- Nielsen, Sebastian R.;
- Strøbech, Jan E.;
- Horton, Edward R.;
- Jackstadt, Rene;
- Laitala, Anu;
- Bravo, Marina C.;
- Maltese, Giorgia;
- Jensen, Adina R. D.;
- Reuten, Raphael;
- Rafaeva, Maria;
- Karim, Saadia A.;
- Hwang, Chang-Il;
- Arnes, Luis;
- Tuveson, David A.;
- Sansom, Owen J.;
- Morton, Jennifer P.;
- Erler, Janine T.
Publication type:
Article
An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-21847-4
By:
- Nacke, Marisa;
- Sandilands, Emma;
- Nikolatou, Konstantina;
- Román-Fernández, Álvaro;
- Mason, Susan;
- Patel, Rachana;
- Lilla, Sergio;
- Yelland, Tamas;
- Galbraith, Laura C. A.;
- Freckmann, Eva C.;
- McGarry, Lynn;
- Morton, Jennifer P.;
- Shanks, Emma;
- Leung, Hing Y.;
- Markert, Elke;
- Ismail, Shehab;
- Zanivan, Sara;
- Blyth, Karen;
- Bryant, David M.
Publication type:
Article
Dasatinib inhibits mammary tumour development in a genetically engineered mouse model.
Published in:
Journal of Pathology, 2013, v. 230, n. 4, p. 430, doi. 10.1002/path.4202
By:
- Karim, Saadia A;
- Creedon, Helen;
- Patel, Hitesh;
- Carragher, Neil O;
- Morton, Jennifer P;
- Muller, William J;
- Evans, Thomas RJ;
- Gusterson, Barry;
- Sansom, Owen J;
- Brunton, Valerie G
Publication type:
Article
p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma.
Published in:
Journal of Pathology, 2010, v. 222, n. 2, p. 129, doi. 10.1002/path.2748
By:
- Doyle, Brendan;
- Morton, Jennifer P;
- Delaney, David W;
- Ridgway, Rachel A;
- Wilkins, Julie A;
- Sansom, Owen J
Publication type:
Article
Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-47949-3
By:
- Raymant, Meirion;
- Astuti, Yuliana;
- Alvaro-Espinosa, Laura;
- Green, Daniel;
- Quaranta, Valeria;
- Bellomo, Gaia;
- Glenn, Mark;
- Chandran-Gorner, Vatshala;
- Palmer, Daniel H.;
- Halloran, Christopher;
- Ghaneh, Paula;
- Henderson, Neil C.;
- Morton, Jennifer P.;
- Valiente, Manuel;
- Mielgo, Ainhoa;
- Schmid, Michael C.
Publication type:
Article
Deregulation of RNA polymerase III transcription in cervical epithelium in response to high-risk human papillomavirus.
Published in:
Oncogene, 2005, v. 24, n. 5, p. 880, doi. 10.1038/sj.onc.1208031
By:
- Daly, Nicole L.;
- Arvanitis, Demetrios A.;
- Fairley, Jennifer A.;
- Gomez-Roman, Natividad;
- Morton, Jennifer P.;
- Graham, Sheila V.;
- Spandidos, Demetrios A.;
- White, Robert J.
Publication type:
Article
Heterogeneity in Pancreatic Cancer Fibroblasts—TGFβ as a Master Regulator?
Published in:
Cancers, 2021, v. 13, n. 19, p. 4984, doi. 10.3390/cancers13194984
By:
- Watt, Dale M.;
- Morton, Jennifer P.
Publication type:
Article
NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β‐dependent regulation of PLK4.
Published in:
Molecular Oncology, 2023, v. 17, n. 7, p. 1212, doi. 10.1002/1878-0261.13425
By:
- Whyte, Declan;
- Skalka, George;
- Walsh, Peter;
- Wilczynska, Ania;
- Paul, Nikki R.;
- Mitchell, Claire;
- Nixon, Colin;
- Clarke, William;
- Bushell, Martin;
- Morton, Jennifer P.;
- Murphy, Daniel J.;
- Muthalagu, Nathiya
Publication type:
Article
A complex secretory program orchestrated by the inflammasome controls paracrine senescence.
Published in:
Nature Cell Biology, 2013, v. 15, n. 8, p. 978, doi. 10.1038/ncb2784
By:
- Acosta, Juan Carlos;
- Banito, Ana;
- Wuestefeld, Torsten;
- Georgilis, Athena;
- Janich, Peggy;
- Morton, Jennifer P.;
- Athineos, Dimitris;
- Kang, Tae-Won;
- Lasitschka, Felix;
- Andrulis, Mindaugas;
- Pascual, Gloria;
- Morris, Kelly J.;
- Khan, Sadaf;
- Jin, Hong;
- Dharmalingam, Gopuraja;
- Snijders, Ambrosius P.;
- Carroll, Thomas;
- Capper, David;
- Pritchard, Catrin;
- Inman, Gareth J.
Publication type:
Article
Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling.
Published in:
Nature Cell Biology, 2012, v. 14, n. 1, p. 51, doi. 10.1038/ncb2386
By:
- Sandilands, Emma;
- Serrels, Bryan;
- McEwan, David G.;
- Morton, Jennifer P.;
- Macagno, Juan Pablo;
- McLeod, Kenneth;
- Stevens, Craig;
- Brunton, Valerie G.;
- Langdon, Wallace Y.;
- Vidal, Marcos;
- Sansom, Owen J.;
- Dikic, Ivan;
- Wilkinson, Simon;
- Frame, Margaret C.
Publication type:
Article
Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue.
Published in:
FEBS Journal, 2013, v. 280, n. 21, p. 5177, doi. 10.1111/febs.12348
By:
- Nobis, Max;
- Carragher, Neil O.;
- McGhee, Ewan J.;
- Morton, Jennifer P.;
- Sansom, Owen J.;
- Anderson, Kurt I.;
- Timpson, Paul
Publication type:
Article
Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment.
Published in:
Carcinogenesis, 2014, v. 35, n. 8, p. 1, doi. 10.1093/carcin/bgu108
By:
- Herrmann, David;
- Conway, James R.W.;
- Vennin, Claire;
- Magenau, Astrid;
- Hughes, William G.;
- Morton, jennifer P.;
- Timpson, Paul
Publication type:
Article
Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.
Published in:
Nature Communications, 2017, v. 8, n. 3, p. 14646, doi. 10.1038/ncomms14646
By:
- Gundry, Christine;
- Marco, Sergi;
- Rainero, Elena;
- Miller, Bryan;
- Dornier, Emmanuel;
- Mitchell, Louise;
- Caswell, Patrick T.;
- Campbell, Andrew D.;
- Hogeweg, Anna;
- Sansom, Owen J.;
- Morton, Jennifer P.;
- Norman, Jim C.
Publication type:
Article
MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus.
Published in:
Cell Death & Disease, 2018, v. 9, n. 6, p. 1, doi. 10.1038/s41419-018-0628-4
By:
- Godfrey, Jack D.;
- Morton, Jennifer P.;
- Wilczynska, Ania;
- Sansom, Owen J.;
- Bushell, Martin D.
Publication type:
Article
p53 status determines the role of autophagy in pancreatic tumour development.
Published in:
Nature, 2013, v. 504, n. 7479, p. 296, doi. 10.1038/nature12865
By:
- Rosenfeldt, Mathias T.;
- O'Prey, Jim;
- Morton, Jennifer P.;
- Nixon, Colin;
- MacKay, Gillian;
- Mrowinska, Agata;
- Au, Amy;
- Rai, Taranjit Singh;
- Zheng, Liang;
- Ridgway, Rachel;
- Adams, Peter D.;
- Anderson, Kurt I.;
- Gottlieb, Eyal;
- Sansom, Owen J.;
- Ryan, Kevin M.
Publication type:
Article
Publisher Correction: Genomic instability in mutant p53 cancer cells upon entotic engulfment.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06026-2
By:
- Mackay, Hannah L.;
- Moore, David;
- Hall, Callum;
- Birkbak, Nicolai J.;
- Jamal-Hanjani, Mariam;
- Karim, Saadia A.;
- Phatak, Vinaya M.;
- Piñon, Lucia;
- Morton, Jennifer P.;
- Swanton, Charles;
- Le Quesne, John;
- Muller, Patricia A. J.
Publication type:
Article
Genomic instability in mutant p53 cancer cells upon entotic engulfment.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05368-1
By:
- Mackay, Hannah L.;
- Moore, David;
- Hall, Callum;
- Birkbak, Nicolai J.;
- Jamal-Hanjani, Mariam;
- Karim, Saadia A.;
- Phatak, Vinaya M.;
- Piñon, Lucia;
- Morton, Jennifer P.;
- Swanton, Charles;
- Le Quesne, John;
- Muller, Patricia A. J.
Publication type:
Article
Increased formate overflow is a hallmark of oxidative cancer.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03777-w
By:
- Meiser, Johannes;
- Schuster, Anne;
- Pietzke, Matthias;
- Voorde, Johan Vande;
- Athineos, Dimitris;
- Oizel, Kristell;
- Burgos-Barragan, Guillermo;
- Wit, Niek;
- Dhayade, Sandeep;
- Morton, Jennifer P.;
- Dornier, Emmanuel;
- Sumpton, David;
- Mackay, Gillian M.;
- Blyth, Karen;
- Patel, Ketan J.;
- Niclou, Simone P.;
- Vazquez, Alexei
Publication type:
Article
MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01967-6
By:
- Farrell, Amy S.;
- Joly, Meghan Morrison;
- Allen-Petersen, Brittany L.;
- Worth, Patrick J.;
- Lanciault, Christian;
- Sauer, David;
- Link, Jason;
- Pelz, Carl;
- Heiser, Laura M.;
- Morton, Jennifer P.;
- Muthalagu, Nathiya;
- Hoffman, Megan T.;
- Manning, Sara L.;
- Pratt, Erica D.;
- Kendsersky, Nicholas D.;
- Egbukichi, Nkolika;
- Amery, Taylor S.;
- Thoma, Mary C.;
- Jenny, Zina P.;
- Rhim, Andrew D.
Publication type:
Article
BRD4-mediated repression of p53 is a target for combination therapy in AML.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-020-20378-8
By:
- Latif, Anne-Louise;
- Newcombe, Ashley;
- Li, Sha;
- Gilroy, Kathryn;
- Robertson, Neil A.;
- Lei, Xue;
- Stewart, Helen J. S.;
- Cole, John;
- Terradas, Maria Terradas;
- Rishi, Loveena;
- McGarry, Lynn;
- McKeeve, Claire;
- Reid, Claire;
- Clark, William;
- Campos, Joana;
- Kirschner, Kristina;
- Davis, Andrew;
- Lopez, Jonathan;
- Sakamaki, Jun-ichi;
- Morton, Jennifer P.
Publication type:
Article
MYC-y mice: From tumour initiation to therapeutic targeting of endogenous MYC
Published in:
Molecular Oncology, 2013, v. 7, n. 2, p. 248, doi. 10.1016/j.molonc.2013.02.015
By:
- Morton, Jennifer P.;
- Sansom, Owen J.
Publication type:
Article

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