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- Title
Inhibition of Substance-P-Induced Histamine Release from Rat Peritoneal Mast Cells by 8-Methoxypsoralen Plus Long-Wave Ultraviolet Light Irradiation: Decreased Intracellular Calcium as a Possible Mechanism.
- Authors
Amano, Hiroo; Kurosawa, Motohiro; Miyachi, Yoshiki
- Abstract
Rat peritoneal mast cells purified on a Percoll gradient were activated by substance P (SP) and the effect of 8-methoxypsoralen (8-MOP) plus long-wave ultraviolet light (UVA) irradiation (8-MOP/UVA) on SP-induced histamine release from the cells was investigated. At a concentration of 10[sup –5] M SP caused a significant histamine release. 8-MOP or UVA irradiation alone at the doses used in the present study neither induced a histamine release nor had any significant effects on SP-induced histamine release from mast cells. On the other hand, 8-MOP/UVA inhibited SP-induced histamine release; this inhibition was dependent on the UVA doses (0.5–3.0 J/cm[sup 2] ) and was accompanied by a reduction in the rise in intracellular calcium concentrations ([Ca[sup 2+] ][sub i] ). These data suggest that 8-MOP/UVA inhibits histamine release from SP-activated rat peritoneal mast cells by suppressing the rise in [Ca[sup 2+] ][sub i] .
- Subjects
HISTAMINE; MAST cells; IRRADIATION; BIOGENIC amines; IMIDAZOLES; INFLAMMATORY mediators; CONNECTIVE tissue cells
- Publication
International Archives of Allergy & Immunology, 1998, Vol 115, Issue 1, p55
- ISSN
1018-2438
- Publication type
Article
- DOI
10.1159/000023830