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- Title
Clinical and Histological Characteristics of Papillary Thyroid Microcarcinoma: Results of a Retrospective Study in 243 Patients.
- Authors
Roti, Elio; Rossi, Roberta; Trasforini, Giorgio; Bertelli, Fiorenza; Ambrosio, Maria Rosaria; Busutti, Luciano; Pearce, Elizabeth N.; Braverman, Lewis E.; degli Uberti, Ettore C.
- Abstract
Context: The recognition of thyroid microcarcinoma has increased due to the widespread use of ultrasound-guided fine-needle aspiration biopsies. Objective: The objective of this study was to describe histological and clinical characteristics of papillary thyroid microcarcinoma (PTMC) less than or equal to 1 cm. Design: This study was a retrospective cohort. Setting: This study was conducted at a university hospital endocrine clinic. Patients: Over a 9-yr period, 243 consecutive patients with PTMC were studied. Results: PTMC was an incidental finding at surgery in 21.4% of the PTMC cases. There were no differences in the clinical characteristics between those with incidental PTMC and those with suspected thyroid carcinoma. None of the patients with a cancer less than 8 mm had distant metastases, whereas distant metastases were observed in patients with cancers >/= 8 mm (P </= 0.05). Disease-related mortality was not observed. Conclusions: PTMC is prevalent in the population. Among patients with PTMC, tumor size more than 8 mm is associated with more aggressive disease.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2006, Vol 91, Issue 6, p2171
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/jc.2005-2372