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- Title
Different Central and Peripheral Responses to Leptin in Rhesus Monkeys: Brain Transport May Be Limited.
- Authors
RAMSEY, JON J.; KEMNITZ, JOSEPH W.; COLMAN, RICKI J.; CUNNINGHAM, DAVID; SWICK, ANDREW G.
- Abstract
The purpose of this experiment was to determine the effect of leptin administration on food intake and energy expenditure in rhesus monkeys. Four adult male rhesus monkeys, cannulated in the left lateral cerebral ventricle, were used for all phases of this experiment. Food intake was measured following intracerebroventricular injections of vehicle or three doses (500 ng, 2 μg, and 22 μg) leptin. Leptin administration resulted in a dose-dependent decrease in food intake (P < 0.05), with food intake decreased by an average of 54% at 22 μg leptin. Energy expenditure was also measured at two intracerebroventricular doses of leptin. Energy expenditure was not different (P > 0.10) between placebo and leptin injections at either dose. Food intake was also measured following i.v. injection of 3 mg leptin. In this case, leptin did not alter (P > 0.10) food intake, despite increasing serum leptin levels by as much as 100-fold. These results suggest that leptin is a potent inhibitor of food intake in rhesus monkeys, but this effect requires elevation of leptin concentrations in the cerebrospinal fluid or critical brain sites. The transport system for movement of leptin across the blood-brain barrier may limit the influence of circulating leptin on food intake in monkeys.
- Publication
Journal of Clinical Endocrinology & Metabolism, 1998, Vol 83, Issue 9, p3230
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/jc.83.9.3230