We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Human Leukocyte Antigens and Prognosis in Patients With Head and Neck Cancer: Results of a Prospective Follow-up Study.
- Authors
Tisch, M.; Kyrberg, H.; Weidauer, H.; Mytilineos, J.; Conradt, C.; Opelz, G.; Maier, H.
- Abstract
Background Prognostic information is essential for optimal treatment of patients with head and neck cancer. We studied the relationship of class I and class II human leukocyte antigens (HLA) on prognosis in patients with head and neck cancer. Methods HLA-A, -B, -C and -DR antigens were determined in 209 patients with squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx. The patients were subjected to follow-up investigations for a period of 5 years. Results Five-year survival rates in relation to tumor stage varied between 86% for stage I tumors and 28% for stage IV tumors ( P <.0001, log-rank trend test). The HLA-A11 antigen showed a significant negative correlation with survival. While the 5-year survival of 124 HLA-A11-negative patients was 58%, none of the 17 HLA-A11-positive patients survived 5 years ( P = .0002). A significant negative correlation with survival was also observed for HLA-DR6. While the 5-year survival rate of 106 HLA-DR6-negative patients was 60%, it was only 40% in 35 HLA-DR6-positive patients ( P = .0313). Conclusions If the findings of our study can be confirmed, HLA-A11 and HLA-DR6 might become clinically important supplemental prognostic markers in head and neck cancer.
- Publication
Laryngoscope, 2002, Vol 112, Issue 4, p651
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1097/00005537-200204000-00011