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- Title
In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [<sup>11</sup>C]ABP688 and [<sup>18</sup>F]FPEB
- Authors
DeLorenzo, Christine; Gallezot, Jean-Dominique; Gardus, John; Jie Yang; Planeta, Beata; Nabulsi, Nabeel; Ogden, R. Todd; Labaree, David C.; Huang, Yiyun H.; Mann, J. John; Gasparini, Fabrizio; Xin Lin; Javitch, Jonathan A.; Parsey, Ramin V.; Carson, Richard E.; Esterlis, Irina
- Abstract
Positron emission tomography tracers [11C]ABP688 and [18F]FPEB target the metabotropic glutamate receptor subtype 5 providing quantification of the brain glutamatergic system in vivo. Previous [11C]ABP688 positron emission tomography human test–retest studies indicate that, when performed on the same day, significant binding increases are observed; however, little deviation is reported when scans are >7 days apart. Due to the small cohorts examined previously (eight and five males, respectively), we aimed to replicate the same-day test–retest studies in a larger cohort including both males and females. Results confirmed large within-subject binding differences (ranging from −23% to 108%), suggesting that measurements are greatly affected by study design. We further investigated whether this phenomenon was specific to [11C]ABP688. Using [18F]FPEB and methodology that accounts for residual radioactivity from the test scan, four subjects were scanned twice on the same day. In these subjects, binding estimates increased between 5% and 39% between scans. Consistent with [11C]ABP688, mean absolute test–retest variability was previously reported as <12% when scans were >21 days apart. This replication study and pilot extension to [18F]FPEB suggest that observed within-day binding variation may be due to characteristics of mGluR5; for example, diurnal variation in mGluR5 may affect measurement of this receptor.
- Publication
Journal of Cerebral Blood Flow & Metabolism, 2017, Vol 37, Issue 8, p2716
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1177/0271678X16673646