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- Title
Genomics: Single cells go fully genomic.
- Authors
Rusk, Nicole
- Abstract
The article reports on the study that uses multiple displacement amplification (MDA) to amplify the genetic content of single cells. It shows that the researchers achieved genomic coverage of 93%, allowing them to detect copy-number variations (CNVs) in single cancer cells. Meanwhile, another team of researchers use multiple annealing and looping-based amplification cycles (MALVAC), which allows them to phase 80% of the donor's heterozygous single-nucleotide polymorphisms.
- Subjects
GENETIC research; GENE amplification; GENOMICS; SINGLE nucleotide polymorphisms; CANCER cells
- Publication
Nature Methods, 2013, Vol 10, Issue 3, p190
- ISSN
1548-7091
- Publication type
Article
- DOI
10.1038/nmeth.2391