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- Title
4-Methylenesterols from a Sponge Theonella swinhoei.
- Authors
Jheng-Kun Guo; Ching-Ying Chiang; Mei-Chin Lu; Wen-Been Chang; Jui-Hsin Su
- Abstract
Three new 4-methylenesterols, theonellasterol K (1), acetyltheonellasterol (2) and acetyldehydroconicasterol (3), along with two known sterols, theonellasterol (4) and theonellasterone (5), were isolated from the sponge Theonella swinhoei. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Compound 1 exhibited significant cytotoxic activity against HCT-116, K562 and Molt 4 cancer cell lines.
- Subjects
STEROLS; METHYL groups; ACETYL group; CHEMICAL structure; CELL-mediated cytotoxicity; NUCLEAR magnetic resonance spectroscopy; DATA analysis
- Publication
Marine Drugs, 2012, Vol 10, Issue 7, p1536
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md10071536