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- Title
Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum.
- Authors
Hegazy, Mohamed-Elamir F.; Eldeen, Amira M. Gamal; Shahat, Abdelaaty A.; Abdel-Latif, Fathy F.; Mohamed, Tarik A.; Whittlesey, Bruce R.; Paré, Paul W.
- Abstract
A chemical investigation of an ethyl acetate extract of the Red Sea soft coral Sarcophyton glaucum has led to the isolation of two peroxide diterpenes, 11(S) hydroperoxylsarcoph-12(20)-ene (1), and 12(S)-hydroperoxylsarcoph-10-ene (2), as well as 8-epi-sarcophinone (3). In addition to these three new compounds, two known structures were identified including: ent-sarcophine (4) and sarcophine (5). Structures were elucidated by spectroscopic analysis, with the relative configuration of 1 and 2 confirmed by X-ray diffraction. Isolated compounds were found to be inhibitors of cytochrome P450 1A activity as well as inducers of glutathione S-transferases (GST), quinone reductase (QR), and epoxide hydrolase (mEH) establishing chemo-preventive and tumor anti-initiating activity for these characterized metabolites.
- Subjects
RED Sea; BIOACTIVE compounds; ETHYL acetate; X-ray diffraction; METABOLITES; CYTOCHROME P-450
- Publication
Marine Drugs, 2012, Vol 10, Issue 1, p209
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md10010209