We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Sub-Saharan red cell antigen phenotypes and glucose-6-phosphate dehydrogenase deiciency variants in French Guiana.
- Authors
Petit, Florence; Bailly, Pascal; Chiaroni, Jacques; Mazières, Stéphane
- Abstract
Background: The treatment of Plasmodium vivax infections requires the use of primaquine, which can lead to severe haemolysis in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. However, most of the Latin American countries, which are still endemic for vivax malaria, lack information on the distribution of G6PD deficiency (G6PDd). No survey has been performed so far in French Guiana. Herein, 80 individuals of the French Guianan Noir Marron population were scrutinized for red cell surface antigens of six blood group systems (ABO, Rh, Kell, Kidd, Duffy and MNS) and G6PD genetic polymorphisms. First, the sub-Saharan origin of the red cell phenotypes was assessed in relation with the literature. Then, given that the main sub-Saharan G6PDd variants are expected to be encountered, only the G6PD sequences of exons 4, 5, 6 and 9 were screened. This work aims at appraising the G6PD gene variation in this population, and thus, contributing to the G6PD piecemeal information in Latin America. Results: Ninety-seven percent (97 %) of the red cells are Fy(a- b-), either D+ C- E- c+ e+ or D+ C+ E- c+ e+ and 44 % exhibited the Fya-/Jkb-/S- combined phenotype. Noteworthy is the detection of the G6PD(Val68Met) variant characterized by c.202G > A transition, G6PD(Asn126Asp) variant characterized by c.376A>G transition and G6PD(Asp181Val) variant characterized by c.542A>T transversion of the G6PD gene in 22.5 % of the sample, characteristic of the A-(202), A and Santamaria G6PDd variants, respectively. Conclusions: French Guianan Noir Marron population represents a pool of Rh-D antigen positive, Duffy-negative and G6PD-deicient erythrocytes, the latter accounting for one in every eight persons. The present study provides the first community-based estimation of the frequency of G6PDd polymorphisms in French Guiana. These results contribute to the G6PD genetic background information puzzle in Latin America.
- Subjects
PLASMODIUM vivax; GLUCOSE 6-phosphatase; MALARIA; DEHYDROGENASES; ERYTHROCYTES
- Publication
Malaria Journal, 2016, Vol 13, p1
- ISSN
1475-2875
- Publication type
Article
- DOI
10.1186/s12936-016-1365-8