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- Title
EFFECTS OF GARCINIA ATROVIRIDIS ON SERUM LIPID PROFILES AND THE HISTOLOGY OF AORTA IN ATHEROSCLEROTIC GUINEA PIG.
- Authors
Zakaria, Zaiton; Amran, Adela A. A.; Othman, Faizah; Morat, Paden
- Abstract
Introduction: The fruit extract of Garcinia atroviridis, with solvent methanol, was used to investigate its effect on serum lipid profile and the histology of aorta in guinea pigs induced with high cholesterol diet. Methodology: Twenty four male Dunkin Hartley Guinea pigs were divided to 4 groups. The first group served as control and was given commercial rabbit chow. The second group was forced fed with 1ml G. atroviridis (50 mg/ body weight). The third group was fed with 1% cholesterol diet in food pellet only in order to induce atherosclerosis. The fourth group was given mix feeding (1% cholesterol diet plus G. atroviridis (50 mg/body weight). After two months of the diet treatment, blood and aorta were taken for biochemical analysis and histological studies. Results: The supplementation of G. atroviridis to a high cholesterol diet decreased the serum levels of cholesterol by 26%, LDL 19% and 46% for LDL/ HDL compared to giving only high cholesterol diet. Histological studies showed significant reduction in fat deposition in the aorta of high cholesterol diet animals given G. atroviridis by 36 % compared to the high cholesterol diet group. Conclusion: This study has shown that dietary intake of G. atroviridis had the tendency to decrease all lipid composition levels in the serum and it also reduced fat deposition in the aorta of high cholesterol diet animals.
- Subjects
GARCINIA; FRUIT; BLOOD lipids; AORTA; ATHEROSCLEROSIS; THERAPEUTICS
- Publication
Malaysian Journal of Medical Sciences, 2007, Vol 14, p113
- ISSN
1394-195X
- Publication type
Article